How do I……..

 

 

 

Draw a Structure and Search for Absolute Stereochemistry

 

 

In this example we want to retrieve N-substituted amphetamines with absolute stereochemistry.

 

 

 

1.      Doubleclick the structure area of the CrossFire Commander to open the CrossFire Structure Editor.

 

2.      Click the Benzene ring tool.

 

3.      Click the Edit tool.

 

 

4.      Click a carbon on the benzene ring and drag to draw a bond.  Release the mouse, then click and drag again to draw successive bonds.

 

 

5.      Click and drag to add the bond that will become the stereo bond.

 

6.      Click the middle of this bond.  The Bond Attributes box appears.

 

 

7.      Select Up from the Bond Attributes box.  Click OK.

 

8.      Click the carbon atom that will become a Nitrogen.  Type N in the Atom Attributes box under Symbol. Click OK.

 

9.      Click the To Commander button.

 

 

10.  Under Free Sites, select Hetero Atoms to allow substitution on the N.

 

 

 

11.  Under Stereo select Absolute.

 

12.  Click the Start Search button.